On the milestone of its 20th anniversary, Lifeline Express launched the "Lifeline Express International Saving Mission" to spread boundless love and hopes to cataract patients in the poverty-stricken areas along the "Belt and Road" countries.
By the end of 2025, Lifeline Express had sent ophthalmologists to Sri Lanka, Myanmar, Pakistan, Uzbekistan, Kyrgyzstan and Tajikistan, restoring vision for 4,960 patients.
| Date (Y/M) | Country | Cured No. |
| 2016.11 | Sri Lanka | 503 |
| 2017.10 | Myanmar | 468 |
| 2018.01 | Pakistan | 529 |
| 2019.07 | D.P.R. Korea | 218 |
| 2019.11 | Uzbekistan | 455 |
| 2023.04 | Uzbekistan | 530 |
| 2023.09 | Kyrgyzstan | 668 |
| 2024.05 | Tajikistan | 543 |
| 2024.09 | Kyrgyzstan | 237 |
| 2024.10 | Uzbekistan | 209 |
| 2025.05 | Tajikistan | 30 |
| 2025.10 | Kyrgyzstan | 252 |
| 2025.10 | Uzbekistan | 318 |